7-溴-1H-异色烯-1,3(4H)-二酮合成路线 （共 3 条）
反应条件
1.1: 2 h / Reflux 2.1: triethylamine / tetrahydrofuran / 0.5 h / -5 °C 2.2: 0.5 h / -5 °C 3.1: sodium azide / tetrahydrofuran; water / -5 °C 4.1: benzene / Reflux 5.1: dichloromethane / 2 h / 20 °C 6.1: potassium carbonate / acetonitrile / 60 °C View Scheme
参考文献
Kilikli, Alper A.; Dengiz, Cagatay; Oezcan, Sevil; Balci, Metin
Synthesis, 2011 , # 22 art. no. T71611SS, p. 3697 - 3705
反应条件
thionyl chloride in dichloromethane
Reflux;
参考文献
Ozcan, Sevil; Dengiz, Cagatay; Delioemeroglu, Murat K.; Sahin, Ertan; Balci, Metin
Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1495 - 1497
反应条件
in acetone
T=20°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/67444 A1, 2006 ;
Location in patent: Page/Page column 64-65 ;
WO 2006/067444 A1
