4-(4-甲氧基苯基)-4-氧丁腈合成路线 （共 24 条）
反应条件
water; iodine; sodium hydrogencarbonate in acetone T=0°C; 2 h;
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
NaCN in N-methyl-acetamide
参考文献
Bayer Aktiengesellschaft
Patent: US4014889 A1, 1977 ;
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene Heating;
参考文献
Boger, Dale L.; Mathvink, Robert J.
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1429 - 1443
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
methanesulfonyl chloride T=0 - 20°C; 2 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2768 - 2778
反应条件
1: 55 percent / aluminum chloride / CH2Cl2 / 3 h 2: methanesulfonyl chloride, pyridine / 1 h / 0 °C 3: NH3(gas) / Ambient temperature 4: methanesulfonyl chloride / 2 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2768 - 2778
反应条件
1: 75 percent / pyridine / diethyl ether / a) 0 deg C, 1 h, b) 0 to 25 deg C, 1 h 2: 64 percent / AIBN, Bu3SnH / benzene / 0.5 h / 80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 5 p. 1429 - 1443
反应条件
1: 87 percent / DBU / dimethylformamide 2: 99 percent / KCN / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 6 - 11
反应条件
1: methanesulfonyl chloride, pyridine / 1 h / 0 °C 2: NH3(gas) / Ambient temperature 3: methanesulfonyl chloride / 2 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2768 - 2778
