4-氧代-4-甲苯基丁腈合成路线 （共 14 条）
反应条件
methanol; nickel Hydrogenation;
参考文献
Knott
Journal of the Chemical Society, 1948 , p. 186
反应条件
water; iodine; sodium hydrogencarbonate in acetone
T=0°C; 2 h;
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
samarium in N,N-dimethyl-formamide
T=20°C; 1.5 h;
参考文献
Liu, Yongjun; Zhang, Yongmin
Journal of Chemical Research, 2004 , # 2 p. 163 - 164
反应条件
in tetrahydrofuran
T=0 - 20°C; Grignard Reaction; 3 h; Inert atmosphere;
参考文献
Harikrishna, Kommidi; Rakshit, Ananya; Aidhen, Indrapal Singh
European Journal of Organic Chemistry, 2013 , # 22 p. 4918 - 4932
反应条件
1.1: n-butyllithium / tetrahydrofuran / -40 - -20 °C / |Inert atmosphere
1.2: 3 h / -78 °C / |Inert atmosphere
2.1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere
3.1: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C
View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere
2: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C
View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
1.1: N-bromosuccinmide / 0.25 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / -40 - -20 °C / |Inert atmosphere
2.2: 3 h / -78 °C / |Inert atmosphere
3.1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere
4.1: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C
View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
参考文献
Veenstra,G.E.; Zwanenburg,B.
Tetrahedron, 1978 , vol. 34, p. 1585 - 1592
反应条件
1: (i) THF, (ii) /BRN= 605310/, <PhCH2NMe3>OH
2: aq. HCl
View Scheme
参考文献
Veenstra,G.E.; Zwanenburg,B.
Tetrahedron, 1978 , vol. 34, p. 1585 - 1592
反应条件
1: MCPBA
2: (i) THF, (ii) /BRN= 605310/, <PhCH2NMe3>OH
3: aq. HCl
View Scheme
参考文献
Veenstra,G.E.; Zwanenburg,B.
Tetrahedron, 1978 , vol. 34, p. 1585 - 1592
