diethyl ether; sodium amide anschl. mit Diaethyl-methyl-<3-oxo-pentyl>-ammonium-jodid in Pyridin;

1: (i) NaOEt, (ii) aq. KOH 2: (i) CuI, (ii) /BRN= 3082770/ View Scheme

暂无反应条件数据

1: 92 percent / Dibal-H / toluene / 2 h / -78 °C 2: 89 percent / pyridine / 3 h / 85 °C View Scheme

in various solvent(s) T=25°C; 240 h; rotary shaker (70 rpm), dark, suspension cells of Nicotiana tabacum;

3: 1.) lithium diisopropyl amide / tetrahydrofuran / -78 °C 4: toluene / 10 h / Heating 5: 48percent aq. HF / 1.5 h / 0 °C 6: diethyl ether / 0 °C 7: LiAlH4 / diethyl ether / 3 h 8: 91 percent / pyridine / CH2Cl2 / 0.5 h 9: 91 percent / pyridine / 9 h / Ambient temperature 10: 89 percent / Li, NH3 / tetrahydrofuran / 0.5 h / -78 °C / 1.) -78 deg C, 30 min. 2.) THF, 30 min 11: 100 percent / 48percent aq. HF / acetonitrile / 1 h 12: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 30 min., 2.) CH2Cl2, -78 deg C to room temp. 13: 51 percent / BF3 * Et2O / CH2Cl2; diethyl ether / 2 h 14: 64 percent / toluene / 10 h / Heating 15: 79 percent / 48percent aq. HF / acetonitrile / 0.25 h 16: 100 percent / NaH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme

1: 92 percent / Dibal-H / toluene / 2 h / -78 °C 2: 89 percent / pyridine / 3 h / 85 °C View Scheme

1: 92 percent / Dibal-H / toluene / 2 h / -78 °C 2: 89 percent / pyridine / 3 h / 85 °C View Scheme