2-(4-甲基苯基)-2-氧代乙酸乙酯合成路线 （共 23 条）
反应条件
1: 95 percent / 2 N aq. NaOH 2: α,α-dichloromethyl methyl ether / 1 h / 65 °C View Scheme
参考文献
Enders, Dieter; Stoeckel, Bianca A.; Rembiak, Andreas
Chemical Communications, 2014 , vol. 50, # 34 p. 4489 - 4491
反应条件
1: palladium; ethanol / Hydrogenation 2: aq. NaOH solution View Scheme
参考文献
Kindler; Metzendorf; Kwok
Chemische Berichte, 1943 , vol. 76, p. 308,314
反应条件
tributyl-amine; titanium tetrachloride in dichloromethane; 1,2-dichloro-ethane 12 h; Heating;
参考文献
Kishorebabu, Neela; Periasamy, Mariappan
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2107 - 2109
反应条件
perchloric acid; sulfuric acid; palladium; acetic acid Hydrogenation;
参考文献
Kindler; Metzendorf; Dschi-yin-Kwok
Chemische Berichte, 1943 , vol. 76, p. 308,313
反应条件
1: palladium; ethanol / Hydrogenation 2: aq. NaOH solution View Scheme
参考文献
Kindler; Metzendorf; Kwok
Chemische Berichte, 1943 , vol. 76, p. 308,314
反应条件
aluminium trichloride in chloroform
T=0 - 5°C; 1.33333 h;
参考文献
Itoh, Osamu; Nagata, Takayoshi; Nomura, Isamu; Takanaga, Tetsuya; Sugita, Toshio; Ichikawa, Katsuhiko
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 3 p. 810 - 814
反应条件
in diethyl ether
T=-78°C; 1 h; Inert atmosphere;
参考文献
Infante, Rebeca; Nieto, Javier; Andres, Celia
Chemistry - A European Journal, 2012 , vol. 18, # 14 p. 4375 - 4379
反应条件
1: para-bromotoluene With magnesium in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
2: oxalic acid diethyl ester in tetrahydrofuran
T=-78°C; 2 h; Inert atmosphere;
参考文献
Hayashi, Masashi; Nakamura, Shuichi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 10 p. 2249 - 2252
反应条件
1: 4-methyl-chlorobenzene With lithium in diethyl ether
T=3 - 6°C;
2: With copper (I) cyanide in tetrahydrofuran; diethyl ether
T=3 - 6°C; 0.416667 h; Cooling with ice;
3: oxalic acid monoethyl ester chloride in tetrahydrofuran; diethyl ether
T=3 - 20°C; 1.25 h;
参考文献
Screttas, Constantinos G.; Steele, Barry R.; Micha-Screttas, Maria; Heropoulos, Georgios A.
Organic Letters, 2012 , vol. 14, # 22 p. 5680 - 5683
反应条件
copper(l) iodide; oxygen in acetonitrile
T=25°C; 2 h;
参考文献
Kim, Se Hee; Kim, Ko Hoon; Kim, Jae Nyoung
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 18 p. 3335 - 3339
