2-(4-甲基苯基)-2-氧代乙酸乙酯合成路线 （共 23 条）
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0 - 30°C; Friedel-Crafts Acylation; 4 h;
参考文献
Brindisi, Margherita; Gemma, Sandra; Alfano, Gloria; Kshirsagar, Giridhar; Novellino, Ettore; Campiani, Giuseppe; Butini, Stefania
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5387 - 5390
反应条件
in diethyl ether
T=-90°C; 1 h;
参考文献
Kashima, Choji; Shirahata, Yoshie; Tsukamoto, Yoshihiro
Heterocycles, 1998 , vol. 49, # 1 p. 459 - 464
反应条件
2-hydroxy-1,3-isoindolinedione; oxygen; anhydrous cobalt diacetate in acetic acid
T=40°C; Oxidation; 24 h;
参考文献
Wentzel, Bastienne B; Donners, Maurice P.J; Alsters, Paul L; Feiters, Martinus C; Nolte, Roeland J.M
Tetrahedron, 2000 , vol. 56, # 39 p. 7797 - 7803
反应条件
1: With boron trifluoride diethyl etherate in acetonitrile
T=20°C;
2: With ozone in dichloromethane
T=20°C; 2.33333 h;
3: With dimethylsulfide in dichloromethane
参考文献
Gioiello, Antimo; Venturoni, Francesco; Natalini, Benedetto; Pellicciari, Roberto
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3520 - 3523
反应条件
potassium permanganate; aluminium sulphate *12H2O in dichloromethane
T=20°C;
参考文献
Yin, Lu; Jia, Xian; Li, Xingshu; Chan, Albert S.C.
Tetrahedron Asymmetry, 2009 , vol. 20, # 17 p. 2033 - 2037
反应条件
1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / Inert atmosphere; Reflux
2: copper(l) iodide; oxygen / acetonitrile / 2 h / 25 °C
View Scheme
参考文献
Kim, Se Hee; Kim, Ko Hoon; Kim, Jae Nyoung
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 18 p. 3335 - 3339
反应条件
aluminium trichloride in chloroform
24 h; Ambient temperaturemodification without solvent (other time); Title compound not separated from byproducts;
参考文献
Itoh, Osamu; Nagata, Takayoshi; Nomura, Isamu; Takanaga, Tetsuya; Sugita, Toshio; Ichikawa, Katsuhiko
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 3 p. 810 - 814
反应条件
magnesium
1.) THF, 2.) -50 deg C up to room temp. within 3h; Yield given. Multistep reaction;
参考文献
Nimitz, Jonathan S.; Mosher, Harry S.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 211 - 213
参考文献
Benincori, Tiziana; Pagani, Silvia Bradamante; Fusco, Raffaello; Sannicolo, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2721 - 2728
参考文献
Claus; Kroseberg
Chemische Berichte, 1887 , vol. 20, p. 2051
