sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=40°C; 12 h;

potassium carbonate 1.) DMF, 80 deg C, 1 h, 2.) a) room temperature, 6 h, b) 95 deg C, 7 h; Yield given. Multistep reaction;

1: aq. AcOH-AcONa buffer, 10 percent aq. NaOH / ethyl acetate / 2 h / Ambient temperature; pH 5.2-5.3 2: 1 N aq. NaOH / 0.17 h / Heating 3: 1.) K2CO3 / 1.) DMF, 80 deg C, 1 h, 2.) a) room temperature, 6 h, b) 95 deg C, 7 h View Scheme