4-羟基-6-苯基吡喃-2-酮合成路线 （共 31 条）
反应条件
T=150 - 180°C; 1.41667 h;
参考文献
Weber; Coudert; Duroux; Leal; Couquelet; Madesclaire
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 11 p. 877 - 884
反应条件
1.1: iPr2NLi / tetrahydrofuran / 1.75 h / -78 °C
1.2: 65 percent / tetrahydrofuran / -78 - 20 °C
2.1: 82 percent / toluene / 0.5 h / Heating
View Scheme
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Hall, C. Dennis; Suzuki, Kazuyuki
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4854 - 4856
反应条件
in benzene
1 h; Heating;
参考文献
Kolesnikova, O. N.; Livantsova, L. I.; Chupina, Yu. M.; Shurov, S. N.; Zaitseva, G. S.; Andreichikov, Yu. S.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 2 p. 406
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 2 p. 458 - 459
反应条件
1: 32 percent / KOH (s) / dimethylsulfoxide / Ambient temperature
2: 11 percent / 30percent aq. H2O2 / acetic acid / 1 h / 40 - 50 °C
3: 92 percent / polyphosphoric acid / 4 h / 100 °C
View Scheme
参考文献
Tominaga, Yoshinori; Ushirogochi, Atsuyuki; Matsuda, Yoshiro
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1557 - 1567
反应条件
1: 99 percent / TiCl4 / CH2Cl2 / 1.5 h / -78 °C
2: 90 percent / Dess-Martin periodinane / CH2Cl2 / 25 °C
3: 72 percent / toluene / 0.17 h / 111 °C
View Scheme
参考文献
Bach; Kirsch
Synlett, 2001 , # 12 p. 1974 - 1976
反应条件
1: 90 percent / Dess-Martin periodinane / CH2Cl2 / 25 °C
2: 72 percent / toluene / 0.17 h / 111 °C
View Scheme
参考文献
Bach; Kirsch
Synlett, 2001 , # 12 p. 1974 - 1976
反应条件
1: 1) LDA, HMPA / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C -> rt
2: 71 percent / toluene / 0.17 h / Heating
View Scheme
参考文献
Sato, Masayuki; Sakaki, Jun-ichi; Sugita, Yoshiaki; Yasuda, Sanae; Sakoda, Hiroko; Kaneko, Chikara
Tetrahedron, 1991 , vol. 47, # 30 p. 5689 - 5708
反应条件
1: 1.) AlCl3, 2.) water, HCl / 1.) reflux, 1 h, 2.) 0-5 deg C, 1 h 40 min
2: 98.6 percent / trifluoroacetic anhydride / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Tanyeli, Cihangir; Tarhan, Okan
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2453 - 2460
反应条件
1: 1.) AlCl3, 2.) water, HCl / 1.) reflux, 1 h, 2.) 0-5 deg C, 1 h 40 min
2: 98.6 percent / trifluoroacetic anhydride / diethyl ether / 2 h / 0 °C
View Scheme
参考文献
Tanyeli, Cihangir; Tarhan, Okan
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2453 - 2460
反应条件
1: tetrahydrofuran
2: 85 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature
3: 1.) LDA, 2.) 10percent HCl / tetrahydrofuran
4: 86.1 percent
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
