1: ortho-methylbenzoic acid With ammonia; lithium in tetrahydrofuran
T=-78°C; Birch reduction; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=-78°C; 1.5 h; Inert atmosphere;
3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Shapland, Peter D.P.; Thomas, Eric J.
Tetrahedron, 2009 , vol. 65, # 21 p. 4201 - 4211