5-甲氧基-4-氧代-1,4-二氢萘-2-羧酸乙酯合成路线 （共 4 条）
反应条件
sodium ethanolate in ethanol
1 h; Heating;
参考文献
MERCK PATENT GMBH
Patent: WO2006/94601 A1, 2006 ;
Location in patent: Page/Page column 62 ;
反应条件
1: 98 percent / K2CO3 / acetone / 4 h / Heating
2: 71 percent / EtONa / ethanol / 10 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
1: 90 percent / aq. NaHCO3 / 3 h / 80 °C
2: 87 percent / HBr; AcOH / 2 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
sodium hydrogencarbonate
T=80°C; 3 h;
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
