1: ethyl 2-(triphenylsilyl)acetate With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=0°C; Metallation; 0.5 h;
2: 3-phenyl-propionaldehyde in tetrahydrofuran; toluene
T=-78°C; Condensation; Peterson reaction; 3 h; Further stages. Title compound not separated from byproducts.;
参考文献
Kojima; Inai; Hidaka; Ohkata
Chemical Communications, 2000 , # 18 p. 1795 - 1796
1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Wadsworth-Emmons reaction; 0.5 h; Inert atmosphere;
2: 3-phenyl-propionaldehyde in tetrahydrofuran; hexane
T=-78 - 20°C; Wadsworth-Emmons reaction; Inert atmosphere; optical yield given as percent de;
参考文献
Claridge, Timothy D. W.; Davies, Stephen G.; Lee, James A.; Nicholson, Rebecca L.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Toms, Steven M.
Organic Letters, 2008 , vol. 10, # 23 p. 5437 - 5440
