2-(5-溴-2,4-二甲氧基苯基)-1,3-二氧戊环合成路线 （共 3 条）
反应条件
1: aq. Na2CO3 / Pd(OAc)2 / 6 h / 100 °C 2: 83 percent / water / p-toluenesulfonic acid / acetone / 20 °C 3: 87.5 percent / ICl / methanol / 3 h / 20 °C View Scheme
参考文献
Meng, Charles Q.; Ni, Liming; Worsencroft, Kimberly J.; Ye, Zhihong; Weingarten, M. David; Simpson, Jacob E.; Skudlarek, Jason W.; Marino, Elaine M.; Suen, Ki-Ling; Kunsch, Charles; Souder, Amy; Howard, Randy B.; Sundell, Cynthia L.; Wasserman, Martin A.; Sikorski, James A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1304 - 1315
反应条件
toluene-4-sulfonic acid in benzene
6 h; Heating;
参考文献
ATHEROGENICS, INC.
Patent: WO2004/56727 A2, 2004 ;
Location in patent: Page 73 ;
反应条件
1: bromine; acetic acid / 2 h / 70 °C
2: toluene-4-sulfonic acid / benzene / |Dean-Stark; |Reflux
View Scheme
参考文献
Abusalim, Deyaa I.; Merfeld, Michelle L.; Lash, Timothy D.
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10360 - 10368
