Ba(OH)2*8H2O; BaO in N,N-dimethyl-formamide T=-5°C; 4 h;

in N,N-dimethyl-formamide; benzyl alcohol T=90°C; 1 h;

calcium sulfate; silver(l) oxide in chloroform 16 h;

sodium isopropanolate in N,N-dimethyl-formamide T=20°C; 15 h;

1: 62 percent / p-toluenesulphonic acid / acetonitrile / 60 h / 60 °C 2: 1.) NaH / 1.) THF, 2.) THF 3: NaCNBH3, molecular sieves 3 Angstroem, etheral HCl / tetrahydrofuran / 0.75 h View Scheme

1: 1.) NaH / 1.) THF, 2.) THF 2: NaCNBH3, molecular sieves 3 Angstroem, etheral HCl / tetrahydrofuran / 0.75 h View Scheme

1: 1.) NaH / 1.) THF, 2.) THF 2: NaCNBH3, molecular sieves 3 Angstroem, etheral HCl / tetrahydrofuran / 0.75 h View Scheme

1: 62 percent / p-toluenesulphonic acid / acetonitrile / 60 h / 60 °C 2: 1.) NaH / 1.) THF, 2.) THF 3: NaCNBH3, molecular sieves 3 Angstroem, etheral HCl / tetrahydrofuran / 0.75 h View Scheme

1: 75 percent / pyridine / 24 h / 4 °C 2: 59 percent / tetrabutylammonium fluoride / acetonitrile / 72 h / Heating 3: H2 / 10percent Pd-C / acetic acid / 24 h / 2587.7 Torr / Ambient temperature 4: pyridine / 24 h / Ambient temperature 5: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 6: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 7: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 8: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme