3-甲氧基-2-甲基苯甲酸合成路线 （共 40 条）
反应条件
1: 3-hydroxy-2-methyl-benzoic acid With sodium hydroxide in water T=40°C; pH=5.5 - 10.5; 2: dimethyl sulfate With sodium hydroxide in water T=40 - 45°C; pH=10.4 - 10.6; 4 h; 3: With sodium hydroxide; sulfuric acid more than 3 stages;
参考文献
Bayer Aktiengesellschaft
Patent: EP1371626 A2, 2003 ;
Location in patent: Page 7, 8 ;
反应条件
1: trisodium 1,3,5-naphthalenetrisulfonate With calcium hydroxide powder; sodium hydroxide in water T=190 - 280°C; P=22202.2 Torr; 15.5 h; 2: dimethyl sulfate With sodium hydroxide in water T=40 - 90°C; pH=10.4 - 11; 5 h;
参考文献
Scherer, Johannes; Mueller-Hauck, Friedrich
Patent: US2004/260119 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; water; toluene
参考文献
Ihara Chemical Industry Co., Ltd.
Patent: EP1044980 A1, 2000 ;
参考文献
Bulletin de la Societe Scientifique de Bretagne, , vol. 31, p. Sonderheft S.9,41
反应条件
nitrogen; sodium methylate; dimethyl sulfate in water; dimethyl sulfoxide; ethyl acetate
反应条件
hydrogenchloride; sodium hydroxide; sulfuric acid in tetrahydrofuran; anhydrous xylene; water
参考文献
Ihara Chemical Industry Co., Ltd.
Patent: EP1044980 A1, 2000 ;
反应条件
1: 3-methoxy-benzoic acid With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=0°C; 2 h; 2: methyl iodide in tetrahydrofuran T=0 - 40°C; 2.5 h; 3: With hydrogenchloride T=20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
1.1: aq. NaNO2; H2SO4 / 1 h / 55 °C 1.2: aq. NaOH 2.1: 53.4 percent / 55 - 65 °C View Scheme
参考文献
Steroids, , vol. 65, # 3 p. 117 - 123
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane 1.) -90 deg C, 60 min, 2.) -78 deg C;
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4042 - 4044
反应条件
hydrogenchloride 12 h; Heating;
参考文献
Kruse, Lawrence I.; Ladd, David L.; Harrsch, Peter B.; McCabe, Francis L.; Mong, Shau-Ming; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 409 - 417
