3-甲氧基-2-甲基苯甲酸合成路线 （共 40 条）
参考文献
ROHM AND HAAS COMPANY
Patent: EP984009 A1, 2000 ;
反应条件
1: thionyl chloride / 6 h / Reflux 2: N-bromosuccinmide; 2-(4-biphenylyl)-5-phenyl-oxazole / tetrachloromethane / 80 °C View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1: With lithium borohydride; chloro-trimethyl-silane in tetrahydrofuran T=20°C; 18.1667 h; 2: With methanol in tetrahydrofuran T=0°C;
参考文献
Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8 ;
US 20070203116 A1
反应条件
1: 3-methoxy-2-methyl-benzoic acid With triethylamine in toluene 2: With diphenylphosphoryl azide in toluene T=20 - 100°C; 3 h; 3: tert-butyl alcohol in toluene 7 h; Heating / reflux;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2007/14919 A1, 2007 ;
Location in patent: Page/Page column 82-83 ;
反应条件
in thionyl chloride; dichloromethane
参考文献
Rohm and Haas Company
Patent: US5530028 A1, 1996 ;
反应条件
sodium hydroxide; potassium permanganate
参考文献
Beard,W.Q.; Hauser,C.R.
Journal of Organic Chemistry, 1960 , vol. 25, p. 334 - 343
反应条件
1: thionyl chloride / 6 h / Reflux
2: N-bromosuccinmide; 2-(4-biphenylyl)-5-phenyl-oxazole / tetrachloromethane / 80 °C
3: methanol; ammonia / 2 h / Reflux
4: boron tribromide / 6 h / Reflux
View Scheme
参考文献
Fu, Li Qiang; Ling, Chen Yu; Guo, Xing Sheng; He, Hui Li; Yang, Yu She
Chinese Chemical Letters, 2012 , vol. 23, # 1 p. 9 - 12
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Reflux
2: thionyl chloride / dichloromethane / Reflux
3: N,N-dimethyl-formamide / 20 °C
4: hydrogen; ammonia / Raney Ni / water; methanol / 5 h / 20 °C / 2585.81 Torr
5: water / 50 °C
6: water; hydrogen bromide / 100 °C
7: triethylamine / water; tetrahydrofuran / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; GINN, John; LOWE, Michael D.; SARKO, Christopher Ronald; TASBER, Edward S.; ZHANG, Zhonghua
Patent: US2014/73629 A1, 2014 ;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2003/104216 A1, 2003 ;
Location in patent: Page 39 ;
反应条件
1: thionyl chloride; triethylamine / tetrahydrofuran / 0.33 h / 20 °C
2: 3.7 g / tetrahydrofuran / 2 h
View Scheme
参考文献
Lehmann, Fredrik; Currier, Erika A.; Olsson, Roger; Hacksell, Uli; Luthman, Kristina
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 8 p. 3057 - 3068
