3-氨基-4-苯基氨基苯甲酸合成路线 （共 8 条）
反应条件
1: With hydrogenchloride in toluene 2.75 h; Reflux; 2: With sodium hydroxide in water; toluene T=20°C; 3: With hydrogenchloride in water T=5 - 10°C; pH=~ 4;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2436683 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
bei Erhitzung ueber ihren Schmelzpunkt;
参考文献
Schoepff
Chemische Berichte, 1889 , vol. 22, p. 3287
Chemische Berichte, 1890 , vol. 23, p. 1842
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2436683 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
in methanol
T=20°C; Reflux;
参考文献
Brink, Mikael; Dahlen, Anders; Olsson, Thomas; Polla, Magnus; Svensson, Tor
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2261 - 2268
反应条件
1: Cu, N-methylmorpholine / 3-methyl-butan-1-ol / 18 h / Heating
2: H2 / 5 percent Pd/C / methanol / 3 h
View Scheme
参考文献
Palmer, Brian D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 27 p. 5457 - 5465
反应条件
1: Cu, N-methylmorpholine / 3-methyl-butan-1-ol / 18 h / Heating
2: H2 / 5 percent Pd/C / methanol / 3 h
View Scheme
参考文献
Palmer, Brian D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 27 p. 5457 - 5465
反应条件
1: ethanol / 16 h / Reflux
2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 2.5 h / 20 °C
View Scheme
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2436683 A1, 2012 ;
反应条件
2: alcoholic ammonium sulfide / 120 °C / im Einschlussrohr
View Scheme
参考文献
Schoepff
Chemische Berichte, 1889 , vol. 22, p. 3287
Chemische Berichte, 1890 , vol. 23, p. 1842
