3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
iodine cloride; acetic acid T=20°C; Iodination; 12 h;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 47 percent / HNO3; H2SO4 / 0.5 h / 100 °C 2: 98 percent / POCl3 / dimethylformamide / 4 h / 60 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 55 percent / aq. NaClO3; HCl; AcOH / 0.33 h / 20 °C 2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 95 percent / aq. NaBrO3; HBr; AcOH / 0.33 h / 20 °C 2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 90 percent / H2SO4, HNO3 / H2O / 3 h / -10 °C 2: 96 percent / DDQ, POCl3 / benzene / 3 h / 90 °C 3: 2.) H2SO4 / 1.) DMF, 110 deg C, 2 h, 2.) water, DMF, 90 deg C, 3 h View Scheme
参考文献
Lee, Byoung Se; Lee, Byung Chul; Jun, Jong-Gab; Chi, Dae Yoon
Heterocycles, 1998 , vol. 48, # 12 p. 2637 - 2641
反应条件
chlorosulfonic acid in tetrachloromethane 3 h; Ambient temperature;
参考文献
Nishi; Yamamoto; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 798 - 810
反应条件
palladium T=250 - 260°C;
参考文献
Spaeth; Galinovsky
Chemische Berichte, 1936 , vol. 69, p. 2059
反应条件
phosphorus pentachloride; trichlorophosphate T=140°C;
参考文献
Baeyer
Chemische Berichte, 1879 , vol. 12, p. 1312
Chemische Berichte, 1883 , vol. 16, p. 1478
参考文献
Baeyer
Chemische Berichte, 1879 , vol. 12, p. 1312
Chemische Berichte, 1883 , vol. 16, p. 1478
反应条件
trichlorophosphate Vilsmeier-Haack reaction;
参考文献
Zheng, Chang-Ji; Jiang, Sheng-Ming; Chen, Zhen-Hua; Ye, Bai-Jun; Piao, Hu-Ri
Archiv der Pharmazie, 2011 , vol. 344, # 10 p. 689 - 695
