3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in chloroform T=20°C; 33 h;
参考文献
Itoh, Naoki; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7424 - 7428
反应条件
1: sulfuric acid; nitric acid / water / 0.33 h / 0 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 2.17 h / 0 - 80 °C View Scheme
参考文献
GAWECO, Anderson; TILLEY, Jefferson W.; WALKER, John; PALMER, Samantha; BLINN, James
Patent: WO2013/159095 A1, 2013 ;
反应条件
1: 1,2,3,4-tetrahydroquinolin-2-one With lithium diisopropyl amide in tetrahydrofuran T=-78 - 20°C; 1.5 h; 2: methyl halide in tetrahydrofuran T=-78 - 20°C; 1.5 h;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
lithium diisopropyl amide 1.) THF, hexane, RT, 1.75 h, 2.) THF, hexane, from -78 deg C to RT, overnight; Yield given. Multistep reaction;
参考文献
Robertson; Krushinski; Beedle; Wyss; Pollock; Wilson; Kauffman; Hayes
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1832 - 1840
反应条件
1: 91 percent / ICl; AcOH / 12 h / 20 °C 2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
benzophenone in water; acetonitrile T=20°C; 24 h; Irradiation; chemoselective reaction;
参考文献
Chemical Science, , vol. 4, # 8 p. 3118 - 3123
反应条件
sulfuric acid; nitric acid
参考文献
Zhang, Chun-Bo; Cui, Xun; Hong, Lan; Quan, Zhe-Shan; Piao, Hu-Ri
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4606 - 4609
反应条件
sulfuric acid; nitric acid in water T=-10°C; 3 h;
参考文献
Heterocycles, , vol. 48, # 12 p. 2637 - 2641
反应条件
Verb.2: 1 Mol; unter starker Kuehlung;
参考文献
Ueda
Proceedings of the Imperial Academy (Tokyo), 1939 , vol. 15, p. 148,153
Chem. Zentralbl., 1939 , vol. 110, # II p. 3089
反应条件
1: concentrated sulfuric acid; nitric acid 2: tin; aqueous HCl View Scheme
参考文献
Proceedings of the Imperial Academy (Tokyo), , vol. 15, p. 148,153
Chem. Zentralbl., , vol. 110, # II p. 3089
