3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
hydrogenchloride; sodium chlorate; acetic acid T=20°C; Chlorination; 0.333333 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 14 p. 1559 - 1562
反应条件
1: 90 percent / H2SO4, HNO3 / H2O / 3 h / -10 °C 2: 96 percent / DDQ, POCl3 / benzene / 3 h / 90 °C View Scheme
参考文献
Lee, Byoung Se; Lee, Byung Chul; Jun, Jong-Gab; Chi, Dae Yoon
Heterocycles, 1998 , vol. 48, # 12 p. 2637 - 2641
反应条件
1: 95 percent / aq. NaBrO3; HBr; AcOH / 0.33 h / 20 °C 2: POCl3; DDQ / dimethylformamide / 6 h / 20 °C 3: dimethylformamide / 80 °C 4: 4 M aq. H2SO4 / 80 °C View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Byung Chul; Chi, Dae Yoon; Choe, Yearn Seong; Jeong, Kyung Ja; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1559 - 1562
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 2 h / 0 °C
2: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C
View Scheme
参考文献
Universitat des Saarlandes
Patent: US2011/112067 A1, 2011 ;
US 20110112067 A1
反应条件
1: 1,2,3,4-tetrahydroquinolin-2-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
2: propyl halide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1: 1,2,3,4-tetrahydroquinolin-2-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
2: 3-chloropropyl halide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1: 1,2,3,4-tetrahydroquinolin-2-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
2: 3-fluoropropyl halide in tetrahydrofuran
T=-78 - 20°C; 1.5 h;
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 60 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 78 percent / HNO3; H2SO4 / H2O / 0.08 h / 0 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 90 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 99 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Lee; Chu; Choe; Kim; Chi
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # SUPPL. 1 p. S54-S56
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 90 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 99 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 12 h / 20 °C
3.1: 55 percent / HNO3; H2SO4 / H2O / 12 h / 20 °C
View Scheme
参考文献
Lee; Chu; Choe; Kim; Chi
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # SUPPL. 1 p. S54-S56
