3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 44 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 84 percent / HNO3; H2SO4 / H2O / 0.08 h / 0 °C
3.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; phosphorus oxychloride / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 75 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 89 percent / HNO3; H2SO4 / H2O / 0.08 h / 0 °C
3.1: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; phosphorus oxychloride / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C
1.2: 61 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: 77 percent / HNO3; H2SO4 / H2O / 0.08 h / 0 °C
3.1: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; phosphorus oxychloride / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Lee, Byoung Se; Chu, Soyoung; Lee, Kyo Chul; Lee, Bon-Su; Chi, Dae Yoon; Choe, Yearn Seong; Kim, Sang Eun; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4949 - 4958
反应条件
aluminium trichloride in carbon disulfide
3 h; Heating;
参考文献
Martinez; Walker; Hirschfeld; Bruno; Yang; Maloney
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 620 - 628
反应条件
aluminium trichloride in carbon disulfide
18 h; Heating;
参考文献
Martinez; Walker; Hirschfeld; Bruno; Yang; Maloney
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 620 - 628
反应条件
aluminium trichloride
Friedel-Crafts reaction; Heating;
参考文献
Rorer Pharmaceutical Corporaton
Patent: US4818755 A1, 1989 ;
Title/Abstract Full Text Show Details
Rorer Pharmaceutical Corporation
Patent: US4721721 A1, 1988 ;
反应条件
aluminium trichloride in carbon disulfide
T=50°C; Friedel-Crafts reaction; 2 h;
参考文献
Kawai, Makoto; Ando, Kazuo; Matsumoto, Yukari; Sakurada, Isao; Hirota, Masako; Nakamura, Hiroshi; Ohta, Atsuko; Sudo, Masaki; Hattori, Kazunari; Takashima, Tadashi; Hizue, Masanori; Watanabe, Shuzo; Fujita, Isami; Mizutani, Mayumi; Kawamura, Mitsuhiro
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5558 - 5562
反应条件
1.1: 83 percent / DMAP / acetonitrile / 48 h / 20 °C
2.1: LiBEt3H / tetrahydrofuran / 0.5 h / -78 °C
2.2: 76 percent / NaH / tetrahydrofuran / 0 - 20 °C
3.1: 99 percent / CF3COOH / CH2Cl2 / 1.5 h / 0 °C
View Scheme
参考文献
Perron, Julien; Joseph, Benoit; Merour, Jean-Yves
European Journal of Organic Chemistry, 2004 , # 22 p. 4606 - 4613
反应条件
1: 77 percent / AlCl3
2: sodium sulfite / H2O / 0.5 h / 70 °C
View Scheme
参考文献
Desos, Patrice; Schlewer, Gilbert; Wermuth, Camille Georges
Heterocycles, 1989 , vol. 28, # 2 p. 1085 - 1099
反应条件
aluminium trichloride in carbon disulfide
18 h; Heating;
参考文献
Martinez; Walker; Hirschfeld; Bruno; Yang; Maloney
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 620 - 628
