3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
potassium dichromate; water
参考文献
Journal of the American Chemical Society, , vol. 75, p. 3029
反应条件
tri-ruthenium(0)dodecacarbonyl; tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide; toluene T=20 - 120°C; 6.08 h; Sealed tube; Reagent/catalystSolventTemperature; Overall yield = 89 percent; regioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 136, # 3 p. 1125 - 1131
反应条件
hydrogenchloride; samarium 0.166667 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 8 p. 1422 - 1424
反应条件
1.1: SOCl2; Et3N / CH2Cl2 / 2 h / 23 °C 2.1: TMSCl; pyridine / 0.17 h / 23 °C 2.2: 4-dimethylaminopyridine / CH2Cl2 / 16 h / 23 °C 3.1: tetrabutylammonium fluoride / dimethylsulfoxide / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 12 p. 2163 - 2165
反应条件
1.1: TMSCl; pyridine / 0.17 h / 23 °C 1.2: 4-dimethylaminopyridine / CH2Cl2 / 16 h / 23 °C 2.1: tetrabutylammonium fluoride / dimethylsulfoxide / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 12 p. 2163 - 2165
反应条件
1.1: 90 percent / LiOH / 1,2-dimethoxy-ethane; H2O / 5 h / 23 °C 2.1: SOCl2; Et3N / CH2Cl2 / 2 h / 23 °C 3.1: TMSCl; pyridine / 0.17 h / 23 °C 3.2: 4-dimethylaminopyridine / CH2Cl2 / 16 h / 23 °C 4.1: tetrabutylammonium fluoride / dimethylsulfoxide / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 12 p. 2163 - 2165
反应条件
1: 95 percent / hydrazine hydrate / ethanol / 1 h / Heating 2: 91 percent / Raney nickel W-2 / ethanol / 0.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 17 p. 6739 - 6744
反应条件
water T=37°C; pH=7.4 - 9; Kinetics;
参考文献
WO2009/3970 A1, ;
Page/Page column 10; 44-45; 3/11 - 5/11 ;
反应条件
1: palladium 10 on activated carbon / 24 h / 150 °C / Autoclave 2: palladium 10 on activated carbon; zinc / water; isopropyl alcohol / 40 h / 150 °C / Autoclave View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1826 - 1833
反应条件
2: 90 percent / FeCl3, CH3COOH / CH2Cl2 / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 6 p. 715 - 718
