3,4-二氢-2(1H)-喹啉酮合成路线 （共 181 条）
反应条件
1: acetone 2: aluminium chloride / Verschmelzen View Scheme
参考文献
DE415096 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 339
反应条件
ammonia; water; copper T=140 - 160°C;
参考文献
Monatshefte fuer Chemie, , vol. 34, p. 1176
反应条件
bismuth trifluoromethanesulphonate T=100 - 120°C; Beckmann rearrangement; 0.5 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 3 p. 387 - 390
反应条件
in phosphate buffer T=37°C; pH=7.4;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 18 p. 3889 - 3899
反应条件
1: Ru(bpy)3Cl2*6H2O; camphor-10-sulfonic acid; 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / |Schlenk technique; |Irradiation 2: triethylamine / tetrahydrofuran 3: acetic acid; iron / ethanol / 1.5 h / 80 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 19 art. no. 3889, p. 2699 - 2705
反应条件
1: palladium diacetate; triphenylphosphine; triethylamine 2: hydrogen; Wilkinson's catalyst / tetrahydrofuran; tert-butyl alcohol / 48 h / 1551.49 Torr 3: Ru(bpy)3Cl2*6H2O; 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine; acetic acid / N,N-dimethyl-formamide / 16 h / |Irradiation 4: triethylamine / tetrahydrofuran 5: acetic acid; iron / ethanol / 1.5 h / 80 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 19 art. no. 3889, p. 2699 - 2705
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide 2: trifluoroacetic acid / dichloromethane / 0 °C / |Inert atmosphere 3: aq. buffer / 37 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7573 - 7577
反应条件
1: |Acidic conditions; |Heating 2: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / acetonitrile 3: sodium dithionite / acetonitrile View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1693 - 1698
反应条件
1: |Alkaline conditions 2: |Acidic conditions; |Heating 3: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / acetonitrile 4: sodium dithionite / acetonitrile View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1693 - 1698
反应条件
sodium dithionite in acetonitrile
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1693 - 1698
