草酸二甲酯合成路线

参考文献

Dannhardt, G; Meindl, W; Schober, B D; Kappe, T
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 6 p. 599 - 604

553-90-2草酸二甲酯+

765-43-5环丙甲基酮

167408-67-5

参考文献

BASF SE; MICHROWSKA-PIANOWSKA, Anna, Aleksandra; KORDES, Markus; HUTZLER, Johannes; NEWTON, Trevor, William; EVANS, Richard, Roger; KREUZ, Klaus; GROSSMANN, Klaus; SEITZ, Thomas; KLOET, Andree van der; WITSCHEL, Matthias; PARRA RAPADO, Liliana; LERCHL, Jens
Patent: WO2013/104561 A1, 2013 ;
Location in patent: Page/Page column 49 ;

553-90-2草酸二甲酯

17640-25-4二氯甲氧基乙酸甲酯

参考文献

EXELIXIS, INC.; PATRICK, Kearney
Patent: WO2012/37226 A1, 2012 ;
Location in patent: Page/Page column 125 ;
WO 2012/037226 A1

553-90-2草酸二甲酯

26447-85-82,2-二噻吩基乙醇酸甲酯

参考文献

Mammen, Mathai; Hughes, Adam
Patent: US2004/242622 A1, 2004 ;
Location in patent: Page 29 ;

553-90-2草酸二甲酯+

5713-61-1苯硫基溴化镁

26447-85-82,2-二噻吩基乙醇酸甲酯

参考文献

ONO PHARMACEUTICAL CO., LTD.
Patent: EP1785421 A1, 2007 ;
Location in patent: Page/Page column 40-42 ;

1003-09-42-溴噻吩+

553-90-2草酸二甲酯

26447-85-82,2-二噻吩基乙醇酸甲酯

参考文献

Prat, Maria; Fernandez, Dolors; Buil, M. Antonia; Crespo, Maria I.; Casals, Gaspar; Ferrer, Manuel; Tort, Laia; Castro, Jordi; Monleon, Juan M.; Gavalda, Amadeu; Miralpeix, Montserrat; Ramos, Israel; Domenech, Teresa; Vilella, Dolors; Anton, Francisca; Huerta, Josep M.; Espinosa, Sonia; Lopez, Manuel; Sentellas, Sonia; Gonzalez, Marisa; Alberti, Joan; Segarra, Victor; Cardenas, Alvaro; Beleta, Jorge; Ryder, Hamish
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5076 - 5092

553-90-2草酸二甲酯+

67-56-1甲醇

18370-95-12,2,2-三甲氧基乙酸甲酯

参考文献

Barrett; Carr; Attwood; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 25 p. 4840 - 4856

参考文献

Campbell; Tucker
Journal of the Chemical Society, 1949 , p. 2623,2626

553-90-2草酸二甲酯