2,6-二氯-3-吡啶甲醛合成路线 （共 15 条）
反应条件
1: 2,6-Dichloropyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; 2 h;
参考文献
SUNOVION PHARMACEUTICALS INC.; JONES, Phillip, G.; LEW, Robert; SPEAR, Kerry, L.; XIE, Linghong
Patent: WO2013/169964 A1, 2013 ;
Location in patent: Paragraph 00254; 00255 ;
反应条件
acetic anhydride in acetic acid; dimethyl sulfoxide T=25°C; 48 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/44454 A1, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/044454 A1
反应条件
1: 2,6-Dichloropyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.5 h; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.333333 h;
参考文献
ANORMED INC.
Patent: WO2007/22371 A2, 2007 ;
Location in patent: Page/Page column 61-62 ;
WO 2007/022371 A2
反应条件
1: 2,6-Dichloropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-80°C; 1.66667 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-80°C; 0.666667 h; 3: With water; ammonium chloride in tetrahydrofuran; hexanes
参考文献
BIOLIPOX AB
Patent: WO2006/77401 A1, 2006 ;
Location in patent: Page/Page column 63 ;
WO 2006/077401 A1
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene; benzene 0.5 h; Heating;
参考文献
Heterocycles, , vol. 31, # 6 p. 1097 - 1104
反应条件
1: 93 percent / LiAlH4, AlCl3 / diethyl ether / 3 h / Heating 2: 66 percent / acetic anhydride / acetic acid; dimethylsulfoxide / 48 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 14 p. 2800 - 2802
反应条件
n-butyllithium 1) THF, -80 deg C, 30 min, 2) 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4793 - 4796
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere 2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere View Scheme
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
反应条件
1: toluene-4-sulfonic acid / toluene / 1 h / |Reflux 2: hydrazine hydrate / butan-1-ol / 1 h / 150 °C / |Sealed tube View Scheme
参考文献
SUNOVION PHARMACEUTICALS INC.; JONES, Phillip, G.; LEW, Robert; SPEAR, Kerry, L.; XIE, Linghong
Patent: WO2013/169964 A1, 2013 ;
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.5 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 3 p. 526 - 529
