2,6-二氯-3-吡啶甲醛合成路线 （共 15 条）
参考文献
WO2010/75200 A1, ;
Page/Page column 170 ;
WO 2010/075200 A1
反应条件
1: NaBH4 / tetrahydrofuran / 1 h / 20 °C
2: NH3; Cu / ethanol / 6 h / 120 °C
3: HCl; SOCl2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
反应条件
methanol
T=55°C; 3 h;
参考文献
ARRAY BIOPHARMA INC.; COOK, Adam; HUNT, Kevin, W.; DELISLE, Robert Kirk; ROMOFF, Todd; CLARK, Christopher, T.; KIM, Ganghyeok; CORRETTE, Christopher, P.; DOHERTY, George, A.; BURGESS, Laurence, E.
Patent: WO2010/75200 A1, 2010 ;
Location in patent: Page/Page column 164 ;
WO 2010/075200 A1
反应条件
sodium methylate in methanol
T=20°C;
参考文献
Roy, Patrick J.; Dufresne, Claude; Lachance, Nicolas; Leclerc, Jean-Philippe; Boisvert, Michel; Wang, Zhaoyin; Leblanc, Yves
Synthesis, 2005 , # 16 art. no. M03305SS, p. 2751 - 2757
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere
2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere
3: ethanol; water / 4 h / 80 °C / Inert atmosphere
View Scheme
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
