2,6-二氯-3-(三氟甲基)吡啶合成路线 （共 11 条）
反应条件
1: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 50°C; 21 h; 2: 3-iodo-2,6-dichloropyridine in tetrahydrofuran; N,N-dimethyl-formamide T=50°C;
参考文献
R-tech Ueno, Ltd.
Patent: WO2009/145360 A1, 2009 ;
Location in patent: Page/Page column 111-112 ;
WO 2009/145360 A1
反应条件
trichlorophosphate T=80°C; 17 h; Product distribution / selectivity;
参考文献
CanBas Co., Ltd.
Patent: US2008/275057 A1, 2008 ;
Location in patent: Page/Page column 68; 71 ;
反应条件
in diethyl ether; water
反应条件
1: 89 percent / Et3N; 1-methyl-2-pyrrolidone / 8.5 h / 120 °C 2: 67.5 percent / methanol; tetrahydrofuran / 10 h / Heating 3: 98 percent / H2 / 20 percent Pd(OH)2/C / H2O; methanol; acetic acid / 20 °C / 2353.63 Torr 4: methanol / 0.5 h / Heating 5: 90 percent / aq. H2SO4 / methanol / 20 °C View Scheme
参考文献
Horikawa; Hirokawa; Kato
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1621 - 1627
反应条件
1.1: 60 percent / Et3N / dimethylformamide / 14 h / 20 °C 2.1: 100 percent / NBS / dimethylformamide / 2 h / 20 °C 3.1: methanol / 2 h / Heating 3.2: aq. HCl / methanol / 0.33 h / 5 °C View Scheme
参考文献
Horikawa; Hirokawa; Kato
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1621 - 1627
反应条件
in ethanol; ethyl acetate
参考文献
Carlier, Patrick; Hoof Van, Petrus Josef Cornelis Maria; Muyrers, Josef Cornelius Johannes
Patent: US2004/38985 A1, 2004 ;
反应条件
hydrogen iodide; sodium iodide 24 h; Heating;
参考文献
Newkome, George R.; Moorfield, Charles N.; Sabbaghian, Bahman
Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 953 - 954
反应条件
triethylamine in dimethyl sulfoxide T=120°C; 18 h; Sealed glass bomb;
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/101065 A2, 2012 ;
Location in patent: Page/Page column 135-136 ;
WO 2012/101065 A2
反应条件
1: 60 percent / Et3N / dimethylformamide / 14 h / 20 °C
2: 100 percent / NBS / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Horikawa; Hirokawa; Kato
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1621 - 1627
反应条件
hydrazine in ethanol
T=20°C; 4 h; Product distribution / selectivity;
参考文献
CanBas Co., Ltd.
Patent: US2008/275057 A1, 2008 ;
Location in patent: Page/Page column 68; 71 ;
