2,6-二溴-3-硝基吡啶合成路线 （共 10 条）
反应条件
hydrogen bromide; acetic acid T=80°C; 3 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2006/24666 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/024666 A1
反应条件
nitronium tetrafluoroborate in acetonitrile 20 h; Heating;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; BINCH, Hayley; FANNING, Lev, T.D.; BOTFIELD, Martyn; GROOTENHUIS, Peter, D.J.; VAN GOOR, Fredrick; NUMA, Mehdi, Michel Djamel
Patent: WO2010/48564 A1, 2010 ;
Location in patent: Page/Page column 49-50 ;
反应条件
hydrogen in tetrahydrofuran T=37°C; P=2250.23 Torr; 42 h; chemoselective reaction;
参考文献
Kasparian, Annie J.; Savarin, Cecile; Allgeier, Alan M.; Walker, Shawn D.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9841 - 9844
反应条件
ammonia in ethanol T=20°C; 19 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6348474 B1, 2002 ;
Location in patent: Page column 136 ;
参考文献
Fujisawa Pharmaceutical Co. Ltd.
Patent: US6573274 B1, 2003 ;
反应条件
1: 87 percent / acetic acid; iron / 0.25 h / 80 °C 2: 84 percent / dioxane / 48 h / Heating View Scheme
参考文献
Parlow, John J.; Kurumbail, Ravi G.; Stegeman, Roderick A.; Stevens, Anna M.; Stallings, William C.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 22 p. 4696 - 4701
反应条件
copper; benzoic acid T=180°C; 0.0833333 h;
参考文献
Duffy, Joseph L.; Laali, Kenneth Khosrow
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3006 - 3009
反应条件
magnesium in tetrahydrofuran T=0°C; Bartoli azaindole synthesis;
参考文献
Panchal, Terry; Bailey, Nick; Bamford, Mark; Demont, Emmanuel; Elliott, Richard; Farre-Gutierrez, Irene; Garton, Neil; Hayhow, Thomas; Hutley, Gail; Naylor, Antoinette
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6813 - 6817
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; BINCH, Hayley; FANNING, Lev, T.D.; BOTFIELD, Martyn; GROOTENHUIS, Peter, D.J.; VAN GOOR, Fredrick; NUMA, Mehdi, Michel Djamel
Patent: WO2010/48564 A1, 2010 ;
Location in patent: Page/Page column 50 ;
反应条件
1: 87 percent / acetic acid; iron / 0.25 h / 80 °C
2: 84 percent / dioxane / 48 h / Heating
3: titanium(IV) chloride / CH2Cl2 / 3 h / 20 °C
4: 5.7 g / sodium cyanoborohydride / CH2Cl2 / 14 h / 20 °C
View Scheme
参考文献
Parlow, John J.; Kurumbail, Ravi G.; Stegeman, Roderick A.; Stevens, Anna M.; Stallings, William C.; South, Michael S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 22 p. 4696 - 4701
