2,6-二溴吡啶-3-甲醛合成路线 (共 3 条)
反应条件
1: 2,6-Dibromopyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: formic acid methyl ester in tetrahydrofuran T=-78°C; 2 h; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
WO2006/21848 A1, ;
Page/Page column 30 ;
WO 2006/021848 A1
反应条件
1: 2,6-Dibromopyridine With n-butyllithium in tetrahydrofuran T=-78°C; 2: N,N-dimethyl-formamide in tetrahydrofuran Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 20 p. 6775 - 6786
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; 2 h;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP2143724 A1, 2010 ;
Location in patent: Page/Page column 25 ;