2,6-二氯-3-羟甲基吡啶合成路线 （共 10 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 2: With water; potassium carbonate in tetrahydrofuran 2 h;
参考文献
WO2006/44454 A1, ;
Page/Page column 62 ;
WO 2006/044454 A1
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.5 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 3 p. 526 - 529
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=0°C; 1 h; 2: With water in diethyl ether
参考文献
WO2007/21710 A1, ;
Page/Page column 73 ;
WO 2007/021710 A1
反应条件
sodium hydroxide in methanol
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether 3 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 47, # 14 p. 2800 - 2802
反应条件
1: nBuLi; diisopropylamine / tetrahydrofuran / 1 h / -78 - 20 °C 2: NaBH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3463 - 3468
反应条件
acetic anhydride in acetic acid; dimethyl sulfoxide T=25°C; 48 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/44454 A1, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/044454 A1
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane T=0 - 25°C; 6 h; Inert atmosphere;
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
Location in patent: Page/Page column 28-29 ;
反应条件
1: NH3; Cu / ethanol / 6 h / 120 °C
2: HCl; SOCl2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere
2: ethanol; water / 4 h / 80 °C / Inert atmosphere
View Scheme
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
