1-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮合成路线

参考文献

IRM LLC; NOVARTIS AG; CHIANELLI, Donatella; LI, Xiaolin; LIU, Xiaodong; LOREN, Jon; MOLTENI, Valentina; NABAKKA, Juliet; REVESZ, Laszlo; PEREZ, Lawrence B.; BROOKS, Clinton; WRONA, Wojciech; MANLEY, Paul W.; BREITENSTEIN, Werner
Patent: WO2008/58037 A1, 2008 ;
Location in patent: Page/Page column 31 ;
WO 2008/058037 A1

1025716-98-6+

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

641569-94-04-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸+

917392-54-24-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲酯

参考文献

Avila Therapeutics, Inc.
Patent: US2008/300268 A1, 2008 ;
Location in patent: Page/Page column 59-60 ;

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

917392-54-24-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲酯

参考文献

Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 700 - 706

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

726169-73-9阿比特龙

参考文献

Marson, Charles M.; Matthews, Christopher J.; Yiannaki, Elena; Atkinson, Stephen J.; Soden, Peter E.; Shukla, Lena; Lamadema, Nermina; Thomas, N. Shaun B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6156 - 6174

593-85-1碳酸胍+

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

SYNTECH SOLUTION LLC; CHEN, Yongsheng
Patent: WO2010/96395 A1, 2010 ;
Location in patent: Page/Page column 36 ;
WO 2010/096395 A1

50-01-1盐酸胍+

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

El-Deeb, Ibrahim Mustafa; Lee, So Ha
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 3860 - 3874

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

Koroleva; Ignatovich, Zh.V.; Ignatovich; Gusak
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1222 - 1226

506-93-4硝酸胍+

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495

420-04-2单氰胺+

55314-16-41-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮+

88-74-4邻硝基苯胺

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

Koroleva; Ignatovich, Zh.V.; Ignatovich; Gusak
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1222 - 1226

66521-66-24-(3-吡啶基)-2-氨基嘧啶

参考文献

Arioli, Federica; Borrelli, Stella; Colombo, Francesco; Falchi, Federico; Filippi, Irene; Crespan, Emmanuele; Naldini, Antonella; Scalia, Giusy; Silvani, Alessandra; Maga, Giovanni; Carraro, Fabio; Botta, Maurizio; Passarella, Daniele
ChemMedChem, 2011 , vol. 6, # 11 p. 2009 - 2018