1-(3-吡啶基)-3-(二甲氨基)-2-丙烯-1-酮合成路线 （共 35 条）
反应条件
sodium carbonate in isopropyl alcohol
Reflux;
参考文献
Skobridis, Konstantinos; Kinigopoulou, Maria; Theodorou, Vassiliki; Giannousi, Emilia; Russell, Alison; Chauhan, Rakhee; Sala, Roberta; Brownlow, Nicola; Kiriakidis, Serafim; Domin, Jan; Tzakos, Andreas G.; Dibb, Nick J.
ChemMedChem, 2010 , vol. 5, # 1 p. 130 - 139
反应条件
methanesulfonic acid in propan-1-ol
T=80 - 150°C; 5.5 h;
参考文献
Anli, Huang; Xing, Liu; Zelikovitch, Lior; Kaspi, Joseph
Patent: US2006/149061 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide; water / 6 h / 110 - 130 °C
2: hydrazine hydrate / water; methanol / 1 h / 60 °C
View Scheme
参考文献
Islam, Rafiqul; Hossain, Md. Imran; Okamoto, Yoshinari; Nagamatsu, Tomohisa; Anraku, Kensaku; Okawara, Tadashi
Heterocycles, 2014 , vol. 89, # 3 p. 693 - 708
反应条件
1.1: 89 percent / N2H4*H2O / ethanol / 3 h / 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 18 percent / dimethylformamide / 3 h / 20 °C
View Scheme
参考文献
Plate, Ralf; Plaum, Marc J. M.; De Boer, Thijs; Andrews, John S.; Rae, Duncan R.; Gibson, Sam
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 227 - 237
反应条件
in 2-methoxy-ethanol
3 h; Heating;
参考文献
Plate, Ralf; Plaum, Marc J. M.; De Boer, Thijs; Andrews, John S.; Rae, Duncan R.; Gibson, Sam
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 227 - 237
