2,4-二甲基吡啶-3-羧酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide; water in ethanol T=20°C; 24 h; 2: With hydrogenchloride in methanol; ethanol; water T=0°C; pH=7;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2008/318979 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;
US 20080318979 A1
反应条件
1: 60 percent 2: 77 percent View Scheme
参考文献
Recueil: Journal of the Royal Netherlands Chemical Society, , vol. 101, # 5 p. 191 - 192
反应条件
1: With thionyl chloride T=60°C; 1 h; 2: With sodium azide; water in acetone T=70°C; 1 h;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2008/318979 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080318979 A1
反应条件
hydrogen fluoride; 3-chloro-benzenecarboperoxoic acid in methanol; N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Palani, Anandan; Shapiro, Sherry; Josien, Hubert; Bara, Thomas; Clader, John W.; Greenlee, William J.; Cox, Kathleen; Strizki, Julie M.; Baroudy, Bahige M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3143 - 3160
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in acetonitrile
T=20°C; 2 h;
参考文献
Yonetoku, Yasuhiro; Kubota, Hirokazu; Miyazaki, Yoji; Okamoto, Yoshinori; Funatsu, Masashi; Yoshimura-Ishikawa, Noriko; Ishikawa, Jun; Yoshino, Taiji; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 21 p. 9457 - 9466
