2-甲氧基-1-(2,4,6-三羟基苯基)乙酮合成路线 (共 27 条)
参考文献
Balakrishna; Rao; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1949 , vol. <A> 29, p. 394,401
反应条件
1: With triethylamine Allan-Robinson condensation; 0.0833333 h; Heating; 2: With potassium hydroxide in methanol 0.333333 h; sonication;
参考文献
SHENOGEN PHARMA GROUP LTD.
Patent: WO2009/129372 A1, 2009 ;
Location in patent: Page/Page column 37 ;
反应条件
1: With triethylamine Allan-Robinson condensation; 0.0833333 h; Heating; 2: With potassium hydroxide in methanol 0.333333 h; sonication;
参考文献
Daskiewicz, Jean-Baptiste; Depeint, Flore; Viornery, Lionel; Bayet, Christine; Comte-Sarrazin, Geraldine; Comte, Gilles; Gee, Jennifer M.; Johnson, Ian T.; Ndjoko, Karine; Hostettmann, Kurt; Barron, Denis
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2790 - 2804
反应条件
sodium 3,4,5-trimethoxybenzoate T=175°C; Kochen des Reaktionsprodukts mit waessrig-alkoholischer Kalilauge;
参考文献
Kalff; Robinson
Journal of the Chemical Society, 1925 , vol. 127, p. 182
反应条件
1: 1) potassium 3,4-dibenzyloxybenzoate, 2) aq. KOH / 1) 160 deg C, 8 h, 2) MeOH, reflux 2: 99 percent / cyclohexene / Pd(OH)2/C / ethanol / 0.5 h / Heating View Scheme
参考文献
Boers, Frank; Deng, Bo-Liang; Lemiere, Guy; Lepoivre, Jozef; De Groot, Alex; Dommisse, Roger; Vlietinck, Arnold J.
Archiv der Pharmazie, 1997 , vol. 330, # 9-10 p. 313 - 316
反应条件
triethylamine T=165°C; Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Kuhn; Loew
Chemische Berichte, 1944 , vol. 77/79, p. 211,213
反应条件
1: With hydrogenchloride; zinc(II) chloride in diethyl ether
5 h; Cooling with ice;
2: With water
3 h; Reflux;
参考文献
BEIJING SHENOGEN PHARMA GROUP LTD.; Ding, Hongxia; Meng, Kun; Li, Jin
Patent: US2013/303544 A1, 2013 ;
Location in patent: Paragraph 0264 ;
反应条件
hydrogenchloride; sodium sulfate; AlCl3
参考文献
MERCK PATENT GMBH
Patent: US2009/220438 A1, 2009 ;
反应条件
1: ZnCl2, HCl / diethyl ether / 2 h / 0 °C
2: H2O / 0.5 h / Heating
View Scheme
参考文献
Boers, Frank; Deng, Bo-Liang; Lemiere, Guy; Lepoivre, Jozef; De Groot, Alex; Dommisse, Roger; Vlietinck, Arnold J.
Archiv der Pharmazie, 1997 , vol. 330, # 9-10 p. 313 - 316
反应条件
1: sodium benzoate
2: 4.5 g / K2CO3 / acetone / 3 h / Heating
3: 0.5 g / KOH, potassium persulphate, pyridine / H2O
4: 0.3 g / HI / acetic anhydride / 0.5 h / 119 - 120 °C
View Scheme
参考文献
Dwivedi, P.; Kapoor, N. K.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 77 - 78