1,3,6-三甲基-5-硝基-2,4(1H,3H)-嘧啶二酮合成路线 （共 11 条）
反应条件
sulfuric acid; nitric acid
T=0°C; 1 h;
参考文献
Azas, Nadine; Rathelot, Pascal; Djekou, Serge; Delmas, Florence; Gellis; Di Giorgio, Carole; Vanelle, Patrice; Timon-David, Pierre
Farmaco, 2003 , vol. 58, # 12 p. 1263 - 1270
反应条件
dimethyl sulfate in sodium hydroxide
参考文献
Witco Vinyl Additives GmbH
Patent: US6002004 A1, 1999 ;
反应条件
in ethanol; water
12 h; Ambient temperature;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi; Yogo, Motoi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 367 - 373
反应条件
1: 65 percent / 15percent aq. NaOH / 40 h / Heating
2: 79 percent / HNO3, H2SO4 / 0 - 5 °C
View Scheme
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
参考文献
Chromow-Borisow; Jurist
Sb. Statei Obshch. Khim., 1953 , p. 657,660
Chem.Abstr., 1955 , p. 1056
Full Text Show Details
Pfleiderer; Mosthaf
Chemische Berichte, 1957 , vol. 90, p. 738,745
反应条件
1.1: aq. NaOH / 70 °C
1.2: 70 percent / 1 h / 80 °C
2.1: 86 percent / H2SO4; HNO3 / 1 h / 0 °C
View Scheme
参考文献
Azas, Nadine; Rathelot, Pascal; Djekou, Serge; Delmas, Florence; Gellis; Di Giorgio, Carole; Vanelle, Patrice; Timon-David, Pierre
Farmaco, 2003 , vol. 58, # 12 p. 1263 - 1270
反应条件
1: SnCl2; aqueous HCl
3: benzene
View Scheme
参考文献
Senda; Suzui
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 476,478
反应条件
1: 73 percent / 3 h / Heating
2: 67 percent / Zn / acetic acid / 0.5 h / 85 - 95 °C
View Scheme
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
反应条件
nickel
Hydrogenation;
参考文献
Senda; Suzui
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 476,478
反应条件
hydrazine hydrate in isopropyl alcohol
1 h; Heating;
参考文献
Hirota, Kosaku; Yamada, Yoshihiro; Asao, Tetsuji; Senda, Shigeo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 277 - 284
