2-甲氧基-4-(甲基乙基)苯酚合成路线 （共 14 条）
反应条件
1: 1.) n-BuLi / 1.) THF, hexanes, r.t., 4 h 2.) THF, -40 deg C, 30 min then warming up to r.t. for 2 h
2: trifluoroacetic anhydride / acetonitrile
View Scheme
参考文献
Costa, Antonio; Saa, Jose M.
Tetrahedron Letters, 1987 , vol. 28, # 45 p. 5551 - 5554
反应条件
1.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
1.2: tetrahydrofuran; CH2Cl2 / -10 °C
2.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
3.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
4.1: 66 percent / K2CO3 / acetone / 5 h / Heating
5.1: 96 percent / p-TSA; m-CPBA / CH2Cl2 / 4 h / 0 - 20 °C
6.1: 94 percent / triethylamine / CH2Cl2; methanol / 1 h / 20 °C
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
反应条件
1.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
1.2: tetrahydrofuran; CH2Cl2 / -10 °C
2.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
3.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
4.1: HClO2; NaH2PO4; DMS / tetrahydrofuran; H2O / 2 h / 20 °C
5.1: 173.3 g / tetrahydrofuran; methanol
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
反应条件
1.1: n-BuLi / tetrahydrofuran / 4.25 h / -15 - 0 °C
1.2: tetrahydrofuran; CH2Cl2 / -10 °C
2.1: 14.5 g / DDQ / CH2Cl2; H2O / 2 h / 20 °C
3.1: 72 percent / Br2; NaOAc; acetic acid / 8 h / 20 °C
4.1: 66 percent / K2CO3 / acetone / 5 h / Heating
View Scheme
参考文献
Cook, Silas P.; Danishefsky, Samuel J.
Organic Letters, 2006 , vol. 8, # 25 p. 5693 - 5695
