5-肼基-1-苯基-1H-四唑合成路线 （共 5 条）
反应条件
1: With hydrogenchloride; sodium nitrite
T=0°C; 1 h;
2: With acetic acid; zinc
T=10°C; 0.5 h;
参考文献
Yamazaki, Kazuto; Hasegawa, Hirohiko; Umekawa, Kayo; Ueki, Yasuyuki; Ohashi, Naohito; Kanaoka, Masaharu
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1275 - 1278
反应条件
1.1: 80 percent / Pb(OAc)2; aq. KOH / 0.08 h / 100 °C
2.1: 66 percent / NaN3; NH4Cl / dimethylformamide / 2.5 h / 80 °C
3.1: aq. NaNO2; HCl / 1 h / 0 °C
3.2: 28 percent / Zn; aq. AcOH / 0.5 h / 10 °C
View Scheme
参考文献
Yamazaki, Kazuto; Hasegawa, Hirohiko; Umekawa, Kayo; Ueki, Yasuyuki; Ohashi, Naohito; Kanaoka, Masaharu
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1275 - 1278
反应条件
1.1: 66 percent / NaN3; NH4Cl / dimethylformamide / 2.5 h / 80 °C
2.1: aq. NaNO2; HCl / 1 h / 0 °C
2.2: 28 percent / Zn; aq. AcOH / 0.5 h / 10 °C
View Scheme
参考文献
Yamazaki, Kazuto; Hasegawa, Hirohiko; Umekawa, Kayo; Ueki, Yasuyuki; Ohashi, Naohito; Kanaoka, Masaharu
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1275 - 1278
参考文献
Stolle et al.
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2>134, p. 282,297
反应条件
1: CCl4; bromine
2: N2H4+H2O
View Scheme
参考文献
Stolle et al.
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2>134, p. 282,297
