反应条件
1.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 95 - 105 °C 2.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 2327.23 - 2585.81 Torr 3.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.5 h / Reflux 3.2: 10 h / -25 - -15 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux 4.2: 0 - 5 °C View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;