1: ortho-iodochlorobenzene With isopropylmagnesium chloride in tetrahydrofuran T=15 - 20°C; 0.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=20°C; 3: With sodium tetrahydroborate in methanol T=20°C; 1.5 h;

1: ortho-iodochlorobenzene With n-butyllithium in tetrahydrofuran; hexanes 0.5 h; Cooling with acetone-dry ice; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexanes 3 h; 3: With sodium tetrahydroborate in methanol T=20°C; 1 h;

1: 1-bromo-2-chloro-benzene; iso-propylmagnesium bromide in tetrahydrofuran T=0°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=0°C; 1 h;

magnesium in tetrahydrofuran

sulfuric acid in methanol 84 h;