1-N-Boc-4-氰基-4-(2-甲氧基苯基)哌啶合成路线 （共 2 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=60°C; spiroannulation reaction;
参考文献
Patane, Michael A.; DiPardo, Robert M.; Newton, Randall C.; Price, RoseAnn P.; Broten, Theodore P.; Chang, Raymond S.L.; Ransom, Richard W.; Di Salvo, Jerry; Nagarathnam, Dhanapalan; Forray, Carlos; Gluchowski, Charles; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1621 - 1624
反应条件
hydrogenchloride in ethyl acetate
deprotection;
参考文献
Patane, Michael A.; DiPardo, Robert M.; Newton, Randall C.; Price, RoseAnn P.; Broten, Theodore P.; Chang, Raymond S.L.; Ransom, Richard W.; Di Salvo, Jerry; Nagarathnam, Dhanapalan; Forray, Carlos; Gluchowski, Charles; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1621 - 1624
