1-N-Boc-4-(3-氯苯基)-4-氰基哌啶合成路线 （共 3 条）
反应条件
1: (3-chlorophenyl)-acetonitrile With 15-crown-5; sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.583333 h;
2: N-(2,2'-bischloro)diethyl-N-(1,1-dimethylethoxy)carbonyl amine With sodium iodide in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
ARRAY BIOPHARMA INC.; MITCHELL, Ian S.; BLAKE, James F.; XU, Rui; KALLAN, Nicholas C.; XIAO, Dengming; SPENCER, Keith Lee; BENCSIK, Josef R.
Patent: WO2008/6039 A1, 2008 ;
Location in patent: Page/Page column 92 ;
WO 2008/006039 A1
反应条件
18-crown-6 ether; potassium tert-butylate in toluene
12 h; Reflux;
参考文献
GRUENENTHAL GmbH
Patent: US2009/264407 A1, 2009 ;
Location in patent: Page/Page column 68 ;
US 20090264407 A1
反应条件
hydrogen; nickel
T=20°C; P=760.051 Torr; 18 - 96 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2007/125325 A1, 2007 ;
Location in patent: Page/Page column 109-110; 131; 132 ;
WO 2007/125325 A1
