5-氨基-3-环己基-1-甲基-1H-吡唑-4-甲腈合成路线 （共 4 条）
反应条件
1: cyclohexane carboxylic acid chloride; malononitrile With sodium hydride in tetrahydrofuran T=0 - 20°C; 1.5 h; 2: With dimethyl sulfate in tetrahydrofuran 3 h; Heating / reflux; 3: methylhydrazine With triethylamine in tetrahydrofuran T=0°C; 1 h; Heating / reflux;
参考文献
Daiichi Suntory Pharma Co., Ltd.; Daiichi Suntory Biomedical Research Limited
Patent: EP1454897 A1, 2004 ;
Location in patent: Page 24 ;
EP 1454897 A1
反应条件
1: cyclohexane carboxylic acid chloride; malononitrile With sodium hydride in tetrahydrofuran T=0 - 20°C; 1.5 h; 2: dimethyl sulfate 3 h; Heating / reflux; 3: methylhydrazine With triethylamine T=0°C; 1 h; Heating / reflux;
参考文献
DAIICHI SUNTORY PHARMA CO.,LTD.; DAIICHI SUNTORY BIOMEDICAL RESEARCH CO.,LTD.
Patent: WO2004/111054 A1, 2004 ;
Location in patent: Page 29-30 ;
WO 2004/111054 A1
反应条件
methylhydrazine in ethanol 5 h; Heating / reflux;
参考文献
DAIICHI SUNTORY PHARMA CO.,LTD.; DAIICHI SUNTORY BIOMEDICAL RESEARCH CO.,LTD.
Patent: WO2004/111054 A1, 2004 ;
Location in patent: Page 29 ;
WO 2004/111054 A1
反应条件
in ethanol T=20°C; 5 h; Heating / reflux;
参考文献
Daiichi Suntory Pharma Co., Ltd.; Daiichi Suntory Biomedical Research Limited
Patent: EP1454897 A1, 2004 ;
Location in patent: Page 24 ;
EP 1454897 A1
