(4S)-4-羟基异亮氨酸合成路线 （共 11 条）
反应条件
1: With lithium hydroxide; water T=20°C; 2 h; 2: With acetic acid
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 44 ;
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
EP2123629 A1, ;
Page/Page column 15 ;
反应条件
lithium hydroxide in water T=20°C; 24 h;
参考文献
Wang, Qian; Ouazzani, Jamal; Andre Sasaki; Potier, Pierre
European Journal of Organic Chemistry, 2002 , # 5 p. 834 - 839
反应条件
1: With hydrogenchloride; water in 1,4-dioxane 1 h; Heating / reflux; 2: With sodium hydroxide; water in ethanol 20 h; 3: With hydrogenchloride in ethanol; water
参考文献
WO2008/154743 A1, ;
Page/Page column 29 ;
反应条件
hydroxylamine in methanol; water 2 h;
参考文献
EP2123629 A1, ;
Page/Page column 15 ;
反应条件
1: With lithium hydroxide; water T=20°C; 2 h; 2: With acetic acid Product distribution / selectivity;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); Universite Louis Pasteur Strasbourg I
Patent: EP1657236 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
Glu; manganese (II) chloride; Escherichia coli BL21(DE3)/pET-15b-ilvE; Arthrobacter simplex AKU 626 in various solvent(s) T=28°C; pH=7.5; 2 h;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 71, # 7 p. 1607 - 1615
反应条件
1: With lithium hydroxide; water T=20°C; 1 h; 2: With acetic acid Product distribution / selectivity;
参考文献
EP1657236 A1, ;
Page/Page column 10; 11 ;
反应条件
hydroxylamine in water; ethyl acetate 72 h; Product distribution / selectivity;
参考文献
EP2123629 A1, ;
Page/Page column 13 ;
反应条件
1: With sodium hydroxide in water 17 h; Reflux; 2: With hydrogenchloride
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 15 p. 4332 - 4335
