1: With bis(trichloromethyl) carbonate in dichloromethane T=0°C; 2: With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 4 h; Heating / reflux;
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1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C 1.2: 5 h / 65 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / -20 °C 3.1: acetic acid; palladium 10 on activated carbon; hydrogen / 12 h / 20 °C View Scheme
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