反应条件
1: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, from 0 deg C to RT, overnight 2: 1.49 g / 4 N HCl / dioxane / 2 h / Ambient temperature 3: tetrahydrofuran / 3 h / Ambient temperature 4: NH3 / methanol; tetrahydrofuran / 6 h / Ambient temperature 5: H2 / 10percent Pd/C / ethyl acetate / 1 h View Scheme
参考文献
Hirst, Gavin C.; Aquino, Christopher; Birkemo, Lawrence; Croom, Dallas K.; Dezube, Milana; Dougherty Jr., Robert W.; Ervin, Gregory N.; Grizzle, Mary K.; Henke, Brad; James, Michael K.; Johnson, Michael F.; Momtahen, Tanya; Queen, Kennedy L.; Sherrill, Ronald G.; Szewczyk, Jerzy; Willson, Timothy M.; Sugg, Elizabeth E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5236 - 5245