2-(4-甲基-1-哌嗪基)-5-硝基吡啶合成路线 （共 5 条）
反应条件
potassium carbonate in tetrahydrofuran T=80°C; 4 h;
参考文献
Ding, Huaiwei; Chen, Zhe; Zhang, Cunlong; Xin, Tian; Wang, Yini; Song, Hongrui; Jiang, Yuyang; Chen, Yuzong; Xu, Yongnan; Tan, Chunyan
Molecules, 2012 , vol. 17, # 4 p. 4703 - 4716
反应条件
in acetonitrile 1.5 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/147831 A1, 2008 ;
Location in patent: Page/Page column 17 ;
WO 2008/147831 A1
反应条件
copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-ethanone; caesium carbonate in N,N-dimethyl-formamide T=25°C; Ullmann condensation; 19 h; Inert atmosphere;
参考文献
Wang, Deping; Ding, Ke
Chemical Communications, 2009 , # 14 p. 1891 - 1893
反应条件
10 Pd/C; hydrogen in methanol P=1810.07 - 2068.65 Torr; 3 h;
参考文献
Tsou, Hwei-Ru; Otteng, Mercy; Tran, Tritin; Floyd Jr., M. Brawner; Reich, Marvin; Birnberg, Gary; Kutterer, Kristina; Ayral-Kaloustian, Semiramis; Ravi, Malini; Nilakantan, Ramaswamy; Grillo, Mary; McGinnis, John P.; Rabindran, Sridhar K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3507 - 3525
反应条件
1.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr 2.1: Et3N / tetrahydrofuran / 20 °C 3.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 3.2: I2 / tetrahydrofuran / -78 - 0 °C 4.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 5.1: aq. HCl / Heating 6.1: TFA / 130 °C 6.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 7.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365
