5-氨基-2-(4-甲基-1-哌嗪基)吡啶合成路线 （共 5 条）
反应条件
10 Pd/C; hydrogen in methanol P=1810.07 - 2068.65 Torr; 3 h;
参考文献
Tsou, Hwei-Ru; Otteng, Mercy; Tran, Tritin; Floyd Jr., M. Brawner; Reich, Marvin; Birnberg, Gary; Kutterer, Kristina; Ayral-Kaloustian, Semiramis; Ravi, Malini; Nilakantan, Ramaswamy; Grillo, Mary; McGinnis, John P.; Rabindran, Sridhar K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3507 - 3525
反应条件
1: tetrahydrofuran / Heating 2: hydrogen / Pd/C / methanol / 45 °C / 760 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365
反应条件
1: tetrahydrofuran / Heating 2: hydrogen / Pd/C / methanol / 45 °C / 760 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365
反应条件
1: sodium carbonate / water / 0.25 h / 150 °C / Microwave irradiation 2: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM). View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 45 p. 5905 - 5909
反应条件
1.1: Et3N / tetrahydrofuran / 20 °C 2.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 2.2: I2 / tetrahydrofuran / -78 - 0 °C 3.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 4.1: aq. HCl / Heating 5.1: TFA / 130 °C 5.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 6.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365
