1-(二苯基甲基)-N,N-二甲基-3-氮杂环丁胺合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated carbon in methanol; water
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1762568 A1, 2007 ;
Location in patent: Page/Page column 37 ;
反应条件
in water; acetonitrile
T=100°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 95 ;
WO 2013/014448 A1
反应条件
1: triethylamine / CH2Cl2 / Ambient temperature
2: propan-2-ol / 3 h / 70 °C
View Scheme
参考文献
Frigola; Pares; Corbera; Vano; Merce; Torrens; Mas; Valenti
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 801 - 810
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 0 - 90 °C
2: triethylamine / dichloromethane / 1 h / 0 °C
3: water; acetonitrile / 100 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
反应条件
1: methanol / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / ethanol / 0 - 90 °C
3: triethylamine / dichloromethane / 1 h / 0 °C
4: water; acetonitrile / 100 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
反应条件
1.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 2 h / 100 °C
1.2: 2 h / 90 °C
2.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
反应条件
1.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 2 h / 100 °C
1.2: 2 h / 90 °C
2.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
3.1: hydrogenchloride / diethyl ether / 0.67 h / 20 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
