6-氨基-1-甲基-5-(甲基氨基)尿嘧啶合成路线 （共 6 条）
反应条件
in water T=70°C; 4 h;
参考文献
Mueller, Christa E.; Geis, Uli; Hipp, Jo; Schobert, Ulrike; Frobenius, Wolfram; Pawlowski, Maciej; Suzuki, Fumio; Sandoval-Ramirez, Jesus
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4396 - 4405
反应条件
1: sodium bicarbonate; bromine / methanol / 0 - 20 °C 2: H2O / 4 h / 70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 5 p. 775 - 778
反应条件
in water T=65°C; 3 h;
参考文献
Rybar, Alfonz; Hesek, Dusan; Szemes, Fridrich; Alfoeldi, Juraj; Tegza, Marian
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 9 p. 2257 - 2269
参考文献
Zhang, Lei; Zhang, Y. John
Tetrahedron Letters, 2006 , vol. 47, # 5 p. 775 - 778
反应条件
1: 68 percent / 3 h
2: 82 percent / K2CO3 / dimethylformamide / 3 h / 120 °C
View Scheme
参考文献
Rybar, Alfonz; Hesek, Dusan; Szemes, Fridrich; Alfoeldi, Juraj; Tegza, Marian
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 9 p. 2257 - 2269
反应条件
1: 73 percent / pyridine / 0 °C
2: 85 percent / 2 N NaOH / ethanol / 1 h / Heating
3: 80 percent / K2CO3 / dimethylformamide / 48 h / Ambient temperature
View Scheme
参考文献
Mueller, Christa E.; Geis, Uli; Hipp, Jo; Schobert, Ulrike; Frobenius, Wolfram; Pawlowski, Maciej; Suzuki, Fumio; Sandoval-Ramirez, Jesus
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4396 - 4405
