Boc-L-3-(1-萘基)-丙氨酸合成路线 （共 18 条）
反应条件
1: 53 percent / 6 N aq. HCl / 2 h / Heating 2: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 94 percent / 0.17 h / 160 °C 2: 97 percent 3: 53 percent / 6 N aq. HCl / 2 h / Heating 4: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 97 percent 2: 53 percent / 6 N aq. HCl / 2 h / Heating 3: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 90 percent / EtONa / ethanol / 6 h / Heating 2: 87 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature 3: 94 percent / 0.17 h / 160 °C 4: 97 percent 5: 53 percent / 6 N aq. HCl / 2 h / Heating 6: 100 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 40 °C 2: alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene / #tert!-butyl alcohol / 144 h / 37 °C / Resolution of racemate; Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 13 p. 938 - 944
反应条件
1: triethylamine / dichloromethane / 0.33 h / 0 °C 2: dichloromethane / 1 h 3: alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene / #tert!-butyl alcohol / 144 h / 37 °C / Resolution of racemate; Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 13 p. 938 - 944
反应条件
1: triethylamine / dichloromethane / 0.33 h / 0 °C 2: dichloromethane / 1 h 3: alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene / #tert!-butyl alcohol / 144 h / 37 °C / Resolution of racemate; Enzymatic reaction View Scheme
参考文献
D'Arrigo, Paola; Cerioli, Lorenzo; Fiorati, Andrea; Servi, Stefano; Viani, Fiorenza; Tessaro, Davide
Tetrahedron Asymmetry, 2012 , vol. 23, # 13 p. 938 - 944
反应条件
1: triethylamine / dichloromethane / 0.33 h / 0 °C 2: dichloromethane / 1 h 3: alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene / #tert!-butyl alcohol / 144 h / 37 °C / Resolution of racemate; Enzymatic reaction View Scheme
参考文献
D'Arrigo, Paola; Cerioli, Lorenzo; Fiorati, Andrea; Servi, Stefano; Viani, Fiorenza; Tessaro, Davide
Tetrahedron Asymmetry, 2012 , vol. 23, # 13 p. 938 - 944
