Cbz-L-天门冬氨酸 4-叔丁酯合成路线 （共 37 条）
参考文献
Journal of Organic Chemistry, , vol. 28, p. 1251 - 1253
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 1 h;
参考文献
Jadhav, Sandip V.; Misra, Rajkumar; Singh, Sumeet K.; Gopi, Hosahudya N.
Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16256 - 16262
反应条件
1: N-methyl morpholine / ethyl acetate / 0.25 h 2: ethyl acetate; diethyl ether / 4 h / 0 °C 3: silver benzoate, Et3N / methanol 4: 94 percent / 50percent CF3COOH / CH2Cl2 / Ambient temperature View Scheme
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
反应条件
hydrogen; palladium diacetate; carbon in water; isopropyl alcohol T=25°C; P=760.051 Torr; 24 h;
参考文献
Felpin, Francois-Xavier; Fouquet, Eric
Synthesis, 2011 , # 18 art. no. T66211SS, p. 2893 - 2896
反应条件
Yield given. Multistep reaction;
参考文献
The Procter and Gamble Company
Patent: US2003/236296 A1, 2003 ;
Location in patent: Page 30 ;
反应条件
1: (S)-2-benzyloxycarbonylamino-succinic acid 4-tert-butyl ester With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=0°C; 0.416667 h; 2: N-methyl-N'-nitro-N-nitroso-guanidine With potassium hydroxide in tetrahydrofuran; diethyl ether; water T=0°C; 0.25 h; 3: With hydrogen bromide in tetrahydrofuran; diethyl ether; water 0.333333 h;
参考文献
ACTIVX BIOSCIENCES, INC.
Patent: WO2004/33397 A2, 2004 ;
Location in patent: Page 31-32; title page; 1/2 ;
反应条件
4-methyl-morpholine; hydrogen bromide; acetic acid in tetrahydrofuran; diethyl ether
参考文献
Idun Pharmacueticals, Inc.
Patent: US6242422 B1, 2001 ;
反应条件
1.1: ClCO2iBu; NMM / tetrahydrofuran / 0.33 h / -10 °C 1.2: diethyl ether / 0.25 h / 0 °C 2.1: aq. HBr / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Sengupta; Rao, G.Venkateshwar; Dubey
Asian Journal of Chemistry, 2011 , vol. 23, # 12 p. 5517 - 5520
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane 0.75 h; Ambient temperature;
参考文献
Mehta, Anita; Jaouhari, Rabih; Benson, Timothy J.; Douglas, Kenneth T.
Tetrahedron Letters, 1992 , vol. 33, # 37 p. 5441 - 5444
反应条件
4-methyl-morpholine; sodium tetrahydroborate; isobutyl chloroformate in tetrahydrofuran T=-78°C; Reduction; 0.333333 h;
参考文献
Mindt, Thomas; Michel, Urs; Dick
Helvetica Chimica Acta, 1999 , vol. 82, # 11 p. 1960 - 1968
